Solid tumors as well as leukemias and lymphomas show striking changes in nuclear
structure including nuclear size and shape, the number and size of nucleoli, and chromatin …

Introduction Genotype-phenotype correlations in PURA-related neurodevelopmental
disorders (PURA-NDDs) remain unclear. This systematic review aimed to clarify these …

PURA, also known as Pur-alpha, is an evolutionarily conserved DNA/RNA-binding protein
crucial for various cellular processes, including DNA replication, transcriptional regulation …

PURA syndrome is a congenital developmental disorder caused by de novo mutations in the
PURA gene, which encodes a DNA/RNA-binding protein essential for transcriptional and …

Objectives Purine-rich element-binding protein alpha (PURA) regulates gene expression
and is ubiquitously expressed with an enrichment in neural tissues. Pathogenic variants in …

One of the most robust approaches to the prediction of causal driver genes of complex
diseases is to apply reverse engineering methods to infer a gene regulatory network (GRN) …

A correct orchestration of all involved proteins is essential for the definition of the embryonic
axes during Drosophila melanogaster oogenesis. One of the involved proteins is Staufen …

The attention on the protein PURA has increased recently following the discovery of the rare
PURA Syndrome. This neurodevelopmental disorder is caused by de novo mutations in the …