The ichthyoses are a large, heterogeneous group of skin cornification disorders. They can
be inherited or acquired, and result in defective keratinocyte differentiation and abnormal …

The retinoids are a group of compounds including vitamin A and its active metabolite all-
trans-retinoic acid (ATRA). Retinoids regulate a variety of physiological functions in multiple …

Imidazole and benzimidazole rings are the most important nitrogen-containing heterocycles,
which are widely explored and utilized by the pharmaceutical industry for drug discovery …

Hereditary ichthyoses are due to mutations on one or both alleles of more than 30 different
genes, mainly expressed in the upper epidermis. Syndromic as well as nonsyndromic forms …

Данные клинические рекомендации подготовлены совместно с Всероссийской
ассоциацией для больных муковисцидозом, рассмотрены и утверждены на заседании …

COVID-19 is a rapidly spreading disease, which has caught the world by surprise. Millions of
people suffer from illness, and the mortality rates are dramatically high. Currently, there is no …

Photodynamic therapy (PDT) is a temporally and spatially precisely controllable,
noninvasive, and potentially highly efficient method of phototherapy. The three components …

This study presents two new concepts and definitions to the medical literature. One of those
is “endogenous retinoic acid theory” and the other “retinoic acid depletion syndrome”. A new …

These guidelines for the management of congenital ichthyoses have been developed by a
multidisciplinary group of European experts following a systematic review of the current …

Topical and systemic retinoids have long been used in the treatment of ichthyoses and other
disorders of cornification. Due to the need for long‐term use of retinoids for these disorders …