[HTML][HTML] Regulation of IRF3 activation in human antiviral signaling pathways

MAL Hamrashdi, G Brady - Biochemical Pharmacology, 2022 - Elsevier
The interferon regulatory factor (IRF) family of transcription factors play a vital role in the
human innate antiviral immune responses with production of interferons (IFNs) as a hallmark …

[HTML][HTML] Bifurcation of signalling in human innate immune pathways to NF-kB and IRF family activation

A Kusiak, G Brady - Biochemical Pharmacology, 2022 - Elsevier
The human innate immune response can be activated through a wide range of stimuli. This
multi-faceted system can be triggered by a range of immunostimulants including pathogen …

Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node

CR Melo-Silva, LJ Sigal - Cellular & Molecular Immunology, 2024 - nature.com
The interstitial fluids in tissues are constantly drained into the lymph nodes (LNs) as lymph
through afferent lymphatic vessels and from LNs into the blood through efferent lymphatics …

Poxviral strategies to overcome host cell apoptosis

CD Suraweera, MG Hinds, M Kvansakul - Pathogens, 2020 - mdpi.com
Apoptosis is a form of cellular suicide initiated either via extracellular (extrinsic apoptosis) or
intracellular (intrinsic apoptosis) cues. This form of programmed cell death plays a crucial …

How to inhibit nuclear factor-kappa B signaling: lessons from poxviruses

JB Reus, EA Rex, DB Gammon - Pathogens, 2022 - mdpi.com
The Nuclear Factor-kappa B (NF-κB) family of transcription factors regulates key host
inflammatory and antiviral gene expression programs, and thus, is often activated during …

Poxviral ANKR/F-box proteins: substrate adapters for ubiquitylation and more

RJ Ingham, F Loubich Facundo, J Dong - Pathogens, 2022 - mdpi.com
Poxviruses are double-stranded DNA viruses that infect insects and a variety of vertebrate
species. The large genomes of poxviruses contain numerous genes that allow these viruses …

Role of cytokines in poxvirus host tropism and adaptation

MM Rahman, G McFadden - Current opinion in virology, 2022 - Elsevier
Poxviruses are a diverse family of double-stranded DNA viruses that cause mild-to-severe
disease in selective hosts, including humans. Although most poxviruses are restricted to …

[HTML][HTML] 非洲猪瘟病毒免疫逃逸分子机制研究进展

赵旭阳, 靳家鑫, 路闻龙, 张帅, 黄丽, 张改平, 孙爱军… - 畜牧兽医学报, 2022 - xml-data.org
非洲猪瘟(African swine fever, ASF) 是由非洲猪瘟病毒(African swine fever virus, ASFV)
感染猪引起的一种急性, 烈性, 高度接触性传染病, 至今没有研发出安全有效的疫苗 …

Ranavirus replication: new studies provide answers to old questions

JK Jancovich, QY Zhang, VG Chinchar - … : Emerging Pathogens of …, 2024 - Springer
This updated review is presented in two parts. The first, based primarily on work conducted
since the discovery of the first ranavirus in the mid-1960s and extending through 2014 …

Molluscum contagiosum virus protein MC089 inhibits interferon regulatory factor 3 activation

M Al Hamrashdi, C Sanchez Perez… - Journal of General …, 2024 - microbiologyresearch.org
Molluscum contagiosum virus (MCV) is a human-specific poxvirus that causes a highly
common but mild infection characterized by distinctive and persistent papular skin lesions …