Plasma membrane and organelle membranes are home to seven phosphoinositides, an
important class of low-abundance anionic signaling lipids that contribute to cellular functions …

Exocytosis is a multistage process involving a merger between the vesicle and the plasma
membranes, leading to the formation of a fusion pore, a channel, through which secretions …

Ketamine is an antidepressant with rapid therapeutic onset and long-lasting effect, although
the underlying mechanism (s) remain unknown. Using FRET-based nanosensors we found …

It is believed that in regulated exocytosis the vesicle membrane fuses with the plasma
membrane in response to a physiological stimulus. However, in the absence of stimulation …

The plasticity of astrocytes is fundamental for their principal function, maintaining
homeostasis of the central nervous system throughout life, and is associated with diverse …

Since the 1970s, much effort was been expended researching mechanisms of regulated
exocytosis. Early work focused mainly on the role of proteins. Most notably the discovery of …

Neuroendocrine cells contain small and large vesicles, but the functional significance of
vesicle diameter is unclear. We studied unitary exocytic events of prolactin-containing …

Astrocytes are the key homeostatic cells in the central nervous system; initiation of reactive
astrogliosis contributes to neuroinflammation. Pro-inflammatory cytokine interferon γ (IFNγ) …

In the past, vesicle content release was thought to occur immediately and completely after
triggering of exocytosis. However, vesicles may merge with the plasma membrane to form …

Interactive mechanical forces between pairs of individual SNARE proteins synaptobrevin 2
(Sb2) and syntaxin 1A (Sx1A) may be sufficient to mediate vesicle docking. This notion …