First‐in‐class cardiolipin‐protective compound as a therapeutic agent to restore mitochondrial bioenergetics

HH Szeto - British journal of pharmacology, 2014 - Wiley Online Library
A decline in energy is common in aging, and the restoration of mitochondrial bioenergetics
may offer a common approach for the treatment of numerous age‐associated diseases …

Serendipity and the discovery of novel compounds that restore mitochondrial plasticity

HH Szeto, AV Birk - Clinical Pharmacology & Therapeutics, 2014 - Wiley Online Library
The mitochondrial electron transport chain (ETC) plays a central role in energy generation in
the cell. Mitochondrial dysfunctions diminish adenosine triphosphate (ATP) production and …

Mitochondrial dysfunction and beneficial effects of mitochondria-targeted small peptide SS-31 in Diabetes Mellitus and Alzheimer's disease

XW Ding, M Robinson, R Li, H Aldhowayan… - Pharmacological …, 2021 - Elsevier
Diabetes and Alzheimer's disease are common chronic illnesses in the United States and
lack clearly demonstrated therapeutics. Mitochondria, the “powerhouse of the cell”, is …

Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance

H Sampath, JM Ntambi - Journal of Biological Chemistry, 2014 - ASBMB
The skin is the single largest organ in humans, serving as a major barrier to infection, water
loss, and abrasion. The functional diversity of skin requires the synthesis of large amounts of …

Burns: an update on current pharmacotherapy

Y Rojas, CC Finnerty, RS Radhakrishnan… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: The worldwide occurrence of burn injuries remains high despite efforts to
reduce injury incidence through public awareness campaigns and improvements in living …

Mitochondrial oxidative stress induces leaky ryanodine receptor during mechanical ventilation

H Dridi, M Yehya, R Barsotti, S Reiken… - Free Radical Biology …, 2020 - Elsevier
Rationale Ventilator-induced diaphragm dysfunction (VIDD) increases morbidity and
mortality in critical care patients. Although VIDD has been associated with mitochondrial …

Novel pharmacotherapy for burn wounds: what are the advancements

MR Hamblin - Expert opinion on pharmacotherapy, 2019 - Taylor & Francis
Introduction: The prognosis for severe burns has improved significantly over the past 50
years. Meanwhile, burns have become an affliction mainly affecting the less well-developed …

[HTML][HTML] A narrative review of changes in microvascular permeability after burn

Y Chi, X Liu, J Chai - Annals of Translational Medicine, 2021 - ncbi.nlm.nih.gov
Objective We aimed to review and discuss some of the latest research results related to post-
burn pathophysiological changes and provide some clues for future study. Background …

Stealth peptides target cellular powerhouses to fight rare and common age-related diseases

HH Szeto - Protein and Peptide Letters, 2018 - ingentaconnect.com
Background: Mitochondria are the primary source of energy in most tissues. Mitochondrial
dysfunction results in cellular energy deficiency, triggers the production of reactive oxygen …

[HTML][HTML] Mitochondria-targeted antioxidant attenuates high glucose-induced P38 MAPK pathway activation in human neuroblastoma cells

M Cao, J Jiang, Y Du, P Yan - Molecular medicine …, 2012 - spandidos-publications.com
Excessive mitochondrial free radical production and the related mitogen-activated protein
kinase P38 (P38 MAPK) activation are key regulators in the pathogenesis of high glucose …