We report the first examples of hydrophilic 6, 6′-bis (1, 2, 4-triazin-3-yl)-2, 2′-bipyridine
(BTBP) and 2, 9-bis (1, 2, 4-triazin-3-yl)-1, 10-phenanthroline (BTPhen) ligands, and their …

Abstract Different novel 1, 2, 4-triazolo [4, 3-b][1, 2, 4, 5] tetrazines and 1, 2, 4-triazolo [4, 3-
b][1, 2, 4] triazines have been obtained from heterocyclization of 3-substituted-4-amino-5 …

The discovery of cytotoxic drugs is focused on designing a compound structure that directly
affects cancer cells without an impact on normal cells. The mechanism of anticancer activity …

Amoebiasis, a disease caused by Entamoeba histolytica, remains a major health problem
that afflicts several million people worldwide. Moreover, in recent years there has been a …

A one-pot reaction of 6-methyl-3-thioxo-3, 4-dihydro-[1, 2, 4] triazin-5-one 1 with selected
aldehydes 2a-d and chloroacetic acid afforded the respective 2-arylidene-6-methyl-thiazolo …

Abstract Reactions of 3-hyrazino-5, 6-diphenyl-1, 2, 4-triazine with various carbonyl
compounds such as ethyl acetoacetate, acetylacetone, benzoin, isatin, phthalic anhydride …

A series of new N-benzoyl-N'-triazine thiourea derivatives have been synthesized via the
reaction of 4-amino-6-methyl-3-thioxo-3, 4-dihydro-1, 2, 4-triazin-5 (2 H)-one with benzoyl …

MM-129 is a novel inhibitor targeting BTK/PI3K/AKT/mTOR and PD-L1, as it possesses
antitumor activity against colon cancer. To evaluate the safety profile of MM-129, we …

Based on the observed biological activity of 1, 2, 4-triazin-5-one derivatives and their cyclic
analogues, a novel series of 7H-thiazolo [3, 2-b]-1, 2, 4-triazin-7-one derivatives that contain …

A series of 3, 7-dimethyl-pyrazolo [3, 4-e][1, 2, 4] triazin-4-yl thiosemicarbazide derivatives 3–
22 were prepared and evaluated in vitro against HM1: 1MSS strain of Entamoeba histolytica …