Multiscale modeling of the neuromuscular system: coupling neurophysiology and skeletal muscle mechanics

O Röhrle, UŞ Yavuz, T Klotz, F Negro… - … : Systems Biology and …, 2019 - Wiley Online Library
Mathematical models and computer simulations have the great potential to substantially
increase our understanding of the biophysical behavior of the neuromuscular system. This …

A two-muscle, continuum-mechanical forward simulation of the upper limb

O Röhrle, M Sprenger, S Schmitt - Biomechanics and modeling in …, 2017 - Springer
By following the common definition of forward-dynamics simulations, ie predicting movement
based on (neural) muscle activity, this work describes, for the first time, a forward-dynamics …

Surrogate modeling of multiscale models using kernel methods

D Wirtz, N Karajan, B Haasdonk - International Journal for …, 2015 - Wiley Online Library
This work investigates the possibilities of acceleration and approximation of multiscale
systems using kernel methods. The key element is to learn the interface between the …

Modeling the chemoelectromechanical behavior of skeletal muscle using the parallel open‐source software library OpenCMISS

T Heidlauf, O Röhrle - Computational and mathematical …, 2013 - Wiley Online Library
An extensible, flexible, multiscale, and multiphysics model for nonisometric skeletal muscle
behavior is presented. The skeletal muscle chemoelectromechanical model is based on a …

In Vivo Multiscale and Spatially-Dependent Biomechanics Reveals Differential Strain Transfer Hierarchy in Skeletal Muscle

S Ghosh, JG Cimino, AK Scott, FW Damen… - ACS biomaterials …, 2017 - ACS Publications
Biological tissues have a complex hierarchical architecture that spans organ to subcellular
scales and comprises interconnected biophysical and biochemical machinery …

[PDF][PDF] Biomechanics and optimal control simulations of the human upper extremity

R Maas - 2014 - opus4.kobv.de
This work establishes a connection between a recently developed optimal control simulation
method and biomechanical modelling aspects of muscle actuated human motion at the …

[PDF][PDF] Model order reduction of multiscale models using kernel methods

D Wirtz, N Karajan, B Haasdonk - Preprint, University of Stuttgart …, 2013 - academia.edu
This work investigates the possibilities of model order reduction of multiscale systems using
kernel methods. Key element is to learn the interface between the different scales using a …

[PDF][PDF] Research Article Modeling the Chemoelectromechanical Behavior of Skeletal Muscle Using the Parallel Open-Source Software Library OpenCMISS

T Heidlauf, O Röhrle - 2013 - academia.edu
An extensible, flexible, multiscale, and multiphysics model for nonisometric skeletal muscle
behavior is presented. he skeletal muscle chemoelectromechanical model is based on a …