Biocompatible strategies for peptide macrocyclisation
Peptides are increasingly important drug candidates, offering numerous advantages over
conventional small molecules. However, they face significant challenges related to stability …
conventional small molecules. However, they face significant challenges related to stability …
Chemoenzymatic tandem cyclization for the facile synthesis of bicyclic peptides
M Kobayashi, N Onozawa, K Matsuda… - Communications …, 2024 - nature.com
Bicyclic peptides exhibit improved metabolic stabilities and target specificities when
compared to their linear or mono-cyclic counterparts; however, efficient and straightforward …
compared to their linear or mono-cyclic counterparts; however, efficient and straightforward …
A RaPID Response to SARS‐CoV‐2
Genetically encoded peptide libraries are at the forefront of de novo drug discovery. The
RaPID (Random Nonstandard Peptides Integrated Discovery) platform stands out due to the …
RaPID (Random Nonstandard Peptides Integrated Discovery) platform stands out due to the …
Phage-encoded bismuth bicycles enable instant access to targeted bioactive peptides
Genetically encoded libraries play a crucial role in discovering structurally rigid, high-affinity
macrocyclic peptide ligands for therapeutic applications. Bicyclic peptides with metal centres …
macrocyclic peptide ligands for therapeutic applications. Bicyclic peptides with metal centres …
Phage-Encoded Bismuth Bicycles: Instant Access to Targeted Bioactive Peptides
Genetically encoded libraries play a crucial role in discovering structurally rigid, high-affinity
macrocyclic peptide ligands for therapeutic applications. This study represents the first …
macrocyclic peptide ligands for therapeutic applications. This study represents the first …
Clinical application of 99mTc‐labeled peptides for tumor imaging: Current status and future directions
J Shi, S Liu - iRADIOLOGY, 2024 - Wiley Online Library
Targeting receptors overexpressed on cancer cells with radiolabeled peptides has become
a crucial aspect of molecular imaging in oncology. Small peptides offer favorable …
a crucial aspect of molecular imaging in oncology. Small peptides offer favorable …
Stretching the Limits of Bicyclic Peptides: A Novel Approach to MYC Inhibition and Beyond
H Thabussot, ME Beaulieu, L Soucek - 2024 - liebertpub.com
Since the identification of MYC as the most deregulated gene in human cancer and its
validation as a viable therapeutic target, 1 much research has been dedicated to finding …
validation as a viable therapeutic target, 1 much research has been dedicated to finding …