Epigenetic modifications are chemical groups in our DNA (and chromatin) that determine
which genes are active and which are shut off. Importantly, they integrate environmental …

Meiosis is a hallmark of sexual reproduction because it represents the transition from one
life cycle to the next and, in animals, meiosis produces gametes. Why meiosis evolved has …

DNA methylation is mainly catalyzed by three DNA methyltransferase (DNMT) proteins in
mammals. Usually DNMT1 is considered the primary DNMT for maintenance DNA …

Cellular plasticity progressively declines with development and differentiation, yet these
processes can be experimentally reversed by reprogramming somatic cells to induced …

Background/Objectives: One-carbon metabolism is a critical pathway for epigenetic
mechanisms. Circulating biomarkers of one-carbon metabolism have been associated with …

Ten eleven translocation (TET) proteins are tumor suppressors that through their catalytic
activity oxidize 5-methylcytosine to 5-hydroxymethylcytosine, to promote DNA demethylation …

Preeclampsia (PE) is a prevalent and multifaceted pregnancy disorder, characterized by
high blood pressure, edema, proteinuria, and systemic organ dysfunction. It remains one of …

Endocrine-disrupting chemicals (EDCs) are prevalent ecological pollutants that interfere
with hormonal systems and pose serious health risks to the public, especially during critical …

Long noncoding RNAs (lncRNAs) are endogenous noncoding RNAs exceeding 200 bases
in length that are prevalent in malignant tumors and are closely associated with the onset …

Moyamoya disease (MMD) is a type of cerebrovascular disease characterized by occlusion
of the distal end of the internal carotid artery and the formation of collateral blood vessels …