ILAE official report: a practical clinical definition of epilepsy

RS Fisher, C Acevedo, A Arzimanoglou, A Bogacz… - …, 2014 - Wiley Online Library
Epilepsy was defined conceptually in 2005 as a disorder of the brain characterized by an
enduring predisposition to generate epileptic seizures. This definition is usually practically …

Resective epilepsy surgery for drug-resistant focal epilepsy: a review

BC Jobst, GD Cascino - Jama, 2015 - jamanetwork.com
Importance Epilepsy surgery is indicated for patients with focal seizures who do not respond
to appropriate antiepileptic drug therapy consisting of 2 or more medications. Objectives To …

The international consensus classification of Focal Cortical Dysplasia–a critical update 2018

IM Najm, HB Sarnat, I Blümcke - Neuropathology and applied …, 2018 - Wiley Online Library
The Diagnostic Methods commission of the International League against Epilepsy (ILAE)
released a first international consensus classification of Focal Cortical Dysplasia (FCD) in …

Seizure outcome of pediatric epilepsy surgery: systematic review and meta-analyses

E Widjaja, P Jain, L Demoe, A Guttmann, G Tomlinson… - Neurology, 2020 - AAN Enterprises
Objective This systematic review and meta-analyses assessed seizure outcome following
pediatric epilepsy surgery. Methods MEDLINE, EMBASE, and Cochrane were searched for …

Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia: A MELD study

K Wagstyl, K Whitaker, A Raznahan, J Seidlitz… - …, 2022 - Wiley Online Library
Objective Drug‐resistant focal epilepsy is often caused by focal cortical dysplasias (FCDs).
The distribution of these lesions across the cerebral cortex and the impact of lesion location …

Rates and predictors of seizure freedom in resective epilepsy surgery: an update

DJ Englot, EF Chang - Neurosurgical review, 2014 - Springer
Epilepsy is a debilitating neurological disorder affecting approximately 1% of the world's
population. Drug-resistant focal epilepsies are potentially surgically remediable. Although …

Temporal patterns and mechanisms of epilepsy surgery failure

I Najm, L Jehi, A Palmini, J Gonzalez‐Martinez… - …, 2013 - Wiley Online Library
Epilepsy surgery is an accepted treatment option in patients with medically refractory focal
epilepsy. Despite various advances in recording and localization noninvasive and invasive …

Seizure‐onset patterns in focal cortical dysplasia and neurodevelopmental tumors: relationship with surgical prognosis and neuropathologic subtypes

S Lagarde, F Bonini, A McGonigal, P Chauvel… - …, 2016 - Wiley Online Library
Objectives The study of intracerebral electroencephalography (EEG) seizure‐onset patterns
is crucial to accurately define the epileptogenic zone and guide successful surgical …

Focal cortical dysplasia: gene mutations, cell signaling, and therapeutic implications

PH Iffland, PB Crino - Annual Review of Pathology: Mechanisms …, 2017 - annualreviews.org
Focal cortical dysplasias (FCDs) are malformations of cortical development (MCDs) that are
highly associated with medication-resistant epilepsy and are the most common cause of …

Artificial intelligence for the detection of focal cortical dysplasia: Challenges in translating algorithms into clinical practice

L Walger, S Adler, K Wagstyl, L Henschel, B David… - …, 2023 - Wiley Online Library
Focal cortical dysplasias (FCDs) are malformations of cortical development and one of the
most common pathologies causing pharmacoresistant focal epilepsy. Resective …