Despite their widespread Internet availability and use, many of the new drugs of abuse
remain unfamiliar to health care providers. The herbal marijuana alternatives, like K2 or …

Covering: 1990 to 2015 The clerodane diterpenoids are a widespread class of secondary
metabolites and have been found in several hundreds of plant species from various families …

The κ-opioid receptor (KOP) mediates the actions of opioids with hallucinogenic, dysphoric,
and analgesic activities. The design of KOP analgesics devoid of hallucinatory and …

Hallucinogens fall into several different classes, as broadly defined by pharmacological
mechanism of action, and chemical structure. These include psychedelics, entactogens …

Psychedelics probably alter states of consciousness by disrupting how the higher
association cortex governs bottom-up sensory signals. Individual hallucinogenic drugs are …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

The hypothesis that functionally selective G protein–coupled receptor (GPCR) agonists may
have enhanced therapeutic benefits has revitalized interest for many GPCR targets. In …

Covering: 1960s to end of August 2018 Plant glandular trichomes (GTs) are adaptive
structures that are well known as “phytochemical factories” due to their impressive capacity …

Pain remains a very pervasive problem throughout medicine. Classical pain management is
achieved through the use of opiates belonging to the mu opioid receptor (MOR) class, which …

Plant-based drugs of abuse are as old as recorded human history. Although traditional
addictive substances, such as opium, cannabis and coca, have been controlled by the …