Cardiogenesis is a complex developmental process involving multiple overlapping stages of
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …

The study of the cellular and molecular pathogenesis of heart valve disease is an emerging
area of research made possible by the availability of cultures of valve interstitial cells (VICs) …

In recent years, significant advances have been made in the definition of regulatory
pathways that control normal and abnormal cardiac valve development. Here, we review the …

In the heart, autophagy is required for normal cardiac function and also has been implicated
in cardiovascular disease. FoxO transcription factors promote autophagy in skeletal muscle …

Transcriptional regulatory mechanisms of cardiac oxidative stress resistance are not well
defined. FoxO transcription factors are critical mediators of oxidative stress resistance in …

The T-box family transcription factor gene TBX20 acts in a conserved regulatory network,
guiding heart formation and patterning in diverse species. Mouse Tbx20 is expressed in …

The multi-chambered mammalian heart arises from a simple tube by polar elongation,
myocardial differentiation and morphogenesis. Members of the large family of T-box (Tbx) …

Tissue engineered heart valves offer a promising alternative for the replacement of diseased
heart valves avoiding the limitations faced with currently available bioprosthetic and …

Bicuspid aortic valve (BAV), the leading congenital heart disease, occurs in 1%–2% of the
population. Genetic studies suggest that BAV is an autosomal-dominant disease with …

Epicardium-derived cells (EPDCs) invade the myocardium and differentiate into fibroblasts
and vascular smooth muscle (SM) cells, which support the coronary vessels. The …