Abstract Heat Shock Factor 1 (HSF1) is a master regulator of heat shock responsive
signaling. In addition to playing critical roles in cellular heat shock response, emerging …

Maintenance of the cellular proteome or proteostasis is an essential process that when
deregulated leads to diseases like neurological disorders and cancer. Central to …

How the essential eukaryotic chaperonin TRiC/CCT assembles from eight distinct subunits
into a unique double-ring architecture remains undefined. We show TRiC assembly involves …

Background Disrupted protein homeostasis (proteostasis) has been demonstrated to
facilitate the progression of various diseases. The cytosolic T‐complex protein‐1 ring …

The human Usher syndrome (USH) is the most common form of a sensory hereditary
ciliopathy characterized by progressive vision and hearing loss. Mutations in the genes …

Tuberous sclerosis complex (TSC) is a rare, multisystem genetic disorder that leads to the
development of benign tumors in multiple organs and neurological symptoms. TSC clinical …

The cytosolic T-complex protein-1 ring complex (TRiC), also referred as chaperonin
containing TCP-1 (CCT), comprising eight different subunits stacked in double toroidal rings …

The chaperonin containing tailless complex polypeptide 1 (CCT) is a multi-subunit
molecular chaperone. It is found in the cytoplasm of all eukaryotic cells, where the …

The lifecycle of a typical protein—from synthesis through to degradation—is regulated at
almost every stage by molecular chaperones (see Figure 1.1). 1, 2 The initial journey of a …

Las proteínas de choque térmico se describieron como una respuesta intracelular al estrés
calórico; sin embargo, al paso del tiempo, se observó que estas proteínas tienen múltiples …