Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

Different calcium signals in the endothelium and smooth muscle target different types of
Ca2+-sensitive K+ channels to modulate vascular function. These differential calcium …

The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also
by other pathways causing hyperpolarization of the underlying smooth muscle cells. This …

Abstract The voltage-gated Kv1. 3 channel and the Ca 2+-activated IKCa1 K+ channel are
expressed in T cells in a distinct pattern that depends on the state of lymphocyte activation …

Protein complexes that contain chromatin-modifying enzymes have an important role in
regulating gene expression. Recent studies have shown that a single transcription factor, the …

Abstract Calcium (Ca 2+) is a highly versatile second messenger that controls vascular
smooth muscle cell (VSMC) contraction, proliferation, and migration. By means of Ca 2+ …

The three subtypes of calcium‐activated potassium channels (KCa) of large, intermediate
and small conductance (BKCa, IKCa and SKCa) are present in the vascular wall. In healthy …

The Ca2+-activated K+ channel KCa3. 1 regulates membrane potential and calcium
signaling in erythrocytes, activated T and B cells, macrophages, microglia, vascular …

Potassium channels importantly contribute to the regulation of vascular smooth muscle
(VSM) contraction and growth. They are the dominant ion conductance of the VSM cell …