Serum autoantibodies as biomarkers for early cancer detection
HT Tan, J Low, SG Lim, MCM Chung - The FEBS journal, 2009 - Wiley Online Library
Autoantibodies against autologus tumor‐associated antigens have been detected in the
asymptomatic stage of cancer and can thus serve as biomarkers for early cancer diagnosis …
asymptomatic stage of cancer and can thus serve as biomarkers for early cancer diagnosis …
Current concepts and future directions for the assessment of autoantibodies to cellular antigens referred to as anti‐nuclear antibodies
M Mahler, PL Meroni, X Bossuyt… - Journal of immunology …, 2014 - Wiley Online Library
The detection of autoantibodies that target intracellular antigens, commonly termed anti‐
nuclear antibodies (ANA), is a serological hallmark in the diagnosis of systemic autoimmune …
nuclear antibodies (ANA), is a serological hallmark in the diagnosis of systemic autoimmune …
Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes
JO Eidahl, BL Crowe, JA North, CJ McKee… - Nucleic acids …, 2013 - academic.oup.com
Lens epithelium-derived growth factor (LEDGF/p75) tethers lentiviral preintegration
complexes (PICs) to chromatin and is essential for effective HIV-1 replication. LEDGF/p75 …
complexes (PICs) to chromatin and is essential for effective HIV-1 replication. LEDGF/p75 …
LEDGF (p75) promotes DNA-end resection and homologous recombination
M Daugaard, A Baude, K Fugger, LK Povlsen… - Nature structural & …, 2012 - nature.com
Lens epithelium–derived growth factor p75 splice variant (LEDGF) is a chromatin-binding
protein known for its antiapoptotic activity and ability to direct human immunodeficiency virus …
protein known for its antiapoptotic activity and ability to direct human immunodeficiency virus …
Anti-DFS70/LEDGF antibodies are more prevalent in healthy individuals compared to patients with systemic autoimmune rheumatic diseases
M Mahler, T Parker, CL Peebles, LE Andrade… - The Journal of …, 2012 - jrheum.org
Objective. Antinuclear antibodies (ANA) are a serological hallmark of systemic autoimmune
rheumatic diseases (SARD) such as systemic lupus erythematosus (SLE). While a number …
rheumatic diseases (SARD) such as systemic lupus erythematosus (SLE). While a number …
The clinical relevance of anti-DFS70 autoantibodies
K Conrad, N Röber, LEC Andrade, M Mahler - Clinical reviews in allergy & …, 2017 - Springer
Despite all the progress in the establishment of specific autoantibody assays, screening for
antinuclear antibodies (ANA) by indirect immunofluorescence on HEp-2 cells for quality …
antinuclear antibodies (ANA) by indirect immunofluorescence on HEp-2 cells for quality …
Cellular co-factors of HIV-1 integration
B Van Maele, K Busschots, L Vandekerckhove… - Trends in biochemical …, 2006 - cell.com
To achieve productive infection, the reverse transcribed cDNA of human immunodeficiency
virus type 1 (HIV-1) is inserted in the host cell genome. The main protein responsible for this …
virus type 1 (HIV-1) is inserted in the host cell genome. The main protein responsible for this …
A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo
F Turlure, G Maertens, S Rahman… - Nucleic acids …, 2006 - academic.oup.com
Lens epithelium-derived growth factor p75 (LEDGF/p75) is a DNA-binding, transcriptional co-
activator that participates in HIV-1 integration site targeting. Using complementary …
activator that participates in HIV-1 integration site targeting. Using complementary …
Tumor-associated antigen arrays for the serological diagnosis of cancer
CA Casiano, M Mediavilla-Varela, EM Tan - Molecular & cellular …, 2006 - ASBMB
The recognition that human tumors stimulate the production of autoantibodies against
autologous cellular proteins called tumor-associated antigens (TAAs) has opened the door …
autologous cellular proteins called tumor-associated antigens (TAAs) has opened the door …
Integrase, LEDGF/p75 and HIV replication
EM Poeschla - Cellular and molecular life sciences, 2008 - Springer
HIV integrates a DNA copy of its genome into a host cell chromosome in each replication
cycle. The essential DNA cleaving and joining chemistry of integration is known, but there is …
cycle. The essential DNA cleaving and joining chemistry of integration is known, but there is …