The Frank–Starling law of the heart describes the interrelationship between end-diastolic
volume and cardiac ejection volume, a regulatory system that operates on a beat-to-beat …

Two groundbreaking papers published in 1954 laid out the theory of the mechanism of
muscle contraction based on force-generating interactions between myofilaments in the …

Every heartbeat relies on cyclical interactions between myosin thick and actin thin filaments
orchestrated by rising and falling Ca2+ levels. Thin filaments are comprised of two actin …

More than a century of research on the Frank–Starling Law has significantly advanced our
knowledge about the working heart. The Frank–Starling Law mandates that the heart is able …

Cardiac contraction depends on molecular interactions among sarcomeric proteins
coordinated by the rising and falling intracellular Ca2+ levels. Cardiac thin filament (cTF) …

At the level of the myofibrillar proteins, activation of myocardial contraction is thought to
involve switch-like regulation of crossbridge binding to the thin filaments. A central feature of …

Hypertrophic Cardiomyopathy (HCM) is a common primary cardiac disorder defined by a
hypertrophied left ventricle, is one of the main causes of sudden death in young athletes …

Contraction of striated muscle is regulated by a dual mechanism involving both thin, actin-
containing filament and thick, myosin-containing filament. Thin filament is activated by Ca2+ …

Insulin‐like growth factor 1 (IGF1) and neuregulin‐1β (NRG1) play important roles during
cardiac development both individually and synergistically. In this study, we analyze how 3D …

The striated muscle sarcomere is a highly organized and complex enzymatic and structural
organelle. Evolutionary pressures have played a vital role in determining the structure …