YAP and TAZ are transcriptional activators pervasively induced in several human solid
tumours and their functions in cancer cells are the focus of intense investigation. These …

The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Common delivery routes for chemotherapeutics are based on circulation, which faces
clinical limitations to local delivery efficiency, and the conflict between the dose for …

The tumor microenvironment (TME) demonstrates distinct hallmarks, including acidosis,
hypoxia, reactive oxygen species (ROS) generation, and altered ion fluxes, which are crucial …

Organoids are a class of multicellular structures with the capability of self-organizing and the
characteristic of original tissues, they are generated from stem cells in 3D culture in vitro …

Twenty five newly synthesized coumarin scaffold based derivatives were assayed for their in
vitro anticancer activity against MCF-7 breast and PC-3 prostate cancer cell lines and were …

Liquid biopsy strategies enable the noninvasive detection of changes in the levels of
circulating biomarkers in body fluid samples, providing an opportunity to diagnose …

Most tumours are thought to arise through oncogenic cell generation followed by additional
mutations. How a new oncogenic cell primes tumorigenesis by acquiring additional …

Tumorigenesis is a multistage progressive oncogenic process caused by alterations in the
structure and expression level of multiple genes. Normal cells are continuously endowed …

Background Cachexia is a paraneoplastic syndrome related with poor prognosis. The
tumour micro‐environment contributes to systemic inflammation and increased oxidative …