Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …

Pathogen-imposed selection pressures have been paramount during human evolution.
Detecting such selection signatures in ancient and modern human genomes can thus help …

Tissue maintenance and repair depend on the integrated activity of multiple cell types.
Whereas the contributions of epithelial,, immune, and stromal cells, in intestinal tissue …

Horizontal integration of summary statistics from different GWAS traits can be used to
evaluate evidence for their shared genetic causality. One popular method to do this is a …

Innate immune responses vary by pathogen and host genetics. We analyze quantitative trait
loci (eQTLs) and transcriptomes of monocytes from 215 individuals stimulated by fungal …

Background While genome-wide associations studies (GWAS) have successfully elucidated
the genetic architecture of complex human traits and diseases, understanding mechanisms …

Population-based studies to identify disease-associated risk alleles typically require
samples from a large number of individuals. Here, we report a human-induced pluripotent …

Vaccines are among the greatest inventions in medicine, leading to the elimination or
control of numerous diseases, including smallpox, polio, measles, rubella, and, most …

Mucormycosis is an emerging lethal fungal infection in immunocompromised patients.
Mucor circinelloides is a causal agent of mucormycosis and serves as a model system to …

Mucormycoses are deadly invasive infections caused by several fungal species belonging
to the subphylum Mucoromycotina, order Mucorales. Hallmarks of disease progression …