The Nrf2 transcription factor governs the expression of hundreds genes involved in cell
defense against oxidative stress, the hallmark of numerous diseases such as …

The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of
the cellular antioxidant response, controlling the expression of genes that counteract …

Targeting ferroptosis, a unique cell death modality triggered by unrestricted lipid
peroxidation, in cancer therapy is hindered by our incomplete understanding of ferroptosis …

The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO),
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …

Short-chain fatty acids (SCFAs), produced by colonic bacteria and obtained from the diet,
have been linked to beneficial effects on human health associated with their metabolic and …

Oxidative stress is the increase in cellular oxidant concentration in comparison to antioxidant
titer. Toxic insults and many other diseased conditions are mediated through the formation of …

Infection of humans with SARS‐CoV‐2 virus causes a disease known colloquially as
“COVID‐19” with symptoms ranging from asymptomatic to severe pneumonia. Initial …

NRF2, a transcription factor that has been deemed the master regulator of cellular redox
homeostasis, declines with age. NRF2 transcriptionally upregulates genes that combat …

Cancer is one of the major causes of death in the world and its global burden is expected to
continue increasing. In several types of cancers, reactive oxygen species (ROS) have been …

In response to stress signal, nuclear factor‐erythroid 2‐related factor 2 (Nrf2) induces the
expression of target genes involved in antioxidant defense and detoxification. Nrf2 activity is …