Simple Summary Artificial intelligence (AI) technology has been advancing rapidly in recent
years and is being implemented in society. The medical field is no exception, and the clinical …

Several protein lysine methyltransferases and demethylases have been identified to have
critical roles in histone modification. A large body of evidence has indicated that their …

Preserving genome function and stability are paramount for ensuring cellular homeostasis,
an imbalance in which can promote diseases including cancer. In the presence of DNA …

Although reactive oxygen species (ROS)‐mediated tumor treatments are predominant in
clinical applications, ROS‐induced protective autophagy promotes cell survival, especially …

To clarify the mechanisms of diseases, such as cancer, studies analyzing genetic mutations
have been actively conducted for a long time, and a large number of achievements have …

TP53 mutations occur in many different types of cancers that produce mutant p53 proteins.
The mutant p53 proteins have lost wild-type p53 activity and gained new functions that …

Rationale: Glioma is the most common primary malignant brain tumor in adults.
Chemoresistance of temozolomide (TMZ), the first-line chemotherapeutic agent, is a major …

Modulation of chromatin templates in response to cellular cues, including DNA damage,
relies heavily on the post-translation modification of histones. Numerous types of histone …

Histone variants represent chromatin components that diversify the structure and function of
the genome. The variants of H2A, primarily H2A. X, H2A. Z and macroH2A, are well …

Long non-coding RNAs (lncRNAs), including linear lncRNAs and circular RNAs (circRNAs),
exhibit a surprising range of structures. Linear lncRNAs and circRNAs are generated by …