Next-generation high-throughput DNA sequencing technologies have advanced
progressively in sequence-based genomic research and novel biological applications with …

Motivation: The enormous amount of short reads generated by the new DNA sequencing
technologies call for the development of fast and accurate read alignment programs. A first …

MOSAIK is a stable, sensitive and open-source program for mapping second and third-
generation sequencing reads to a reference genome. Uniquely among current mapping …

Motivation: A ubiquitous and fundamental step in high-throughput sequencing analysis is
the alignment (mapping) of the generated reads to a reference sequence. To accomplish …

Motivation: High-throughput sequencing technologies produce very large amounts of data
and sequencing errors constitute one of the major problems in analyzing such data. Current …

Biosilicification—the formation of biological structures composed of silica—has a wide
distribution among eukaryotes; it plays a major role in global biogeochemical cycles, and …

Motivation: The explosion of next-generation sequencing data has spawned the design of
new algorithms and software tools to provide efficient mapping for different read lengths and …

DNA methylation regulates gene expression primarily through modification of chromatin
structure. Global methylation studies have revealed biologically relevant patterns of DNA …

Magnetotactic bacteria (MTB) are a group of prokaryotes that generally live dominantly at or
just below the oxic‐anoxic transition zone (OATZ) in diverse aquatic environments. They …

Magnetotactic bacteria (MTB) are phylogenetically diverse prokaryotes that can produce
intracellular chain‐assembled nanocrystals of magnetite (Fe3O4) or greigite (Fe3S4) …