Regulation, functions and transmission of bivalent chromatin during mammalian development
TA Macrae, J Fothergill-Robinson… - … reviews Molecular cell …, 2023 - nature.com
Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …
landscape that mediates gene expression programmes. During development, mammalian …
Functions and mechanisms of epigenetic inheritance in animals
The idea that epigenetic determinants such as DNA methylation, histone modifications or
RNA can be passed to the next generation through meiotic products (gametes) is long …
RNA can be passed to the next generation through meiotic products (gametes) is long …
Dynamics of the epigenetic landscape during the maternal-to-zygotic transition
MA Eckersley-Maslin, C Alda-Catalinas… - … Reviews Molecular Cell …, 2018 - nature.com
A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …
Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos
Histone modifications have critical roles in regulating the expression of developmental
genes during embryo development in mammals,. However, genome-wide analyses of …
genes during embryo development in mammals,. However, genome-wide analyses of …
Resetting epigenetic memory by reprogramming of histone modifications in mammals
Polycomb group proteins and the related histone modification H3K27me3 can maintain the
silencing of key developmental regulators and provide cellular memory. However, how such …
silencing of key developmental regulators and provide cellular memory. However, how such …
Offspring from oocytes derived from in vitro primordial germ cell–like cells in mice
K Hayashi, S Ogushi, K Kurimoto, S Shimamoto… - Science, 2012 - science.org
Reconstitution of female germ cell development in vitro is a key challenge in reproductive
biology and medicine. We show here that female (XX) embryonic stem cells and induced …
biology and medicine. We show here that female (XX) embryonic stem cells and induced …
Active DNA demethylation: many roads lead to Rome
SC Wu, Y Zhang - Nature reviews Molecular cell biology, 2010 - nature.com
DNA methylation is one of the best-characterized epigenetic modifications and has been
implicated in numerous biological processes, including transposable element silencing …
implicated in numerous biological processes, including transposable element silencing …
Epigenetic programming and reprogramming during development
I Cantone, AG Fisher - Nature structural & molecular biology, 2013 - nature.com
Cell identity is determined by specific gene expression patterns that are conveyed by
interactions between transcription factors and DNA in the context of chromatin. In …
interactions between transcription factors and DNA in the context of chromatin. In …
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency
Summary Trimethylation on H3K27 (H3K27me3) mediated by Polycomb repressive complex
2 (PRC2) has been linked to embryonic stem cell (ESC) identity and pluripotency. EZH2, the …
2 (PRC2) has been linked to embryonic stem cell (ESC) identity and pluripotency. EZH2, the …
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer
Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that
contributes to the epigenetic silencing of target genes and regulates the survival and …
contributes to the epigenetic silencing of target genes and regulates the survival and …