Hydrostatic pressure sensing by WNK kinases

JM Humphreys, LR Teixeira, R Akella… - Molecular biology of …, 2023 - Am Soc Cell Biol
Previous study has demonstrated that the WNK kinases 1 and 3 are direct osmosensors
consistent with their established role in cell-volume control. WNK kinases may also be …

WNKs are potassium-sensitive kinases

JM Pleinis, L Norrell, R Akella… - … of Physiology-Cell …, 2021 - journals.physiology.org
With no lysine (K)(WNK) kinases regulate epithelial ion transport in the kidney to maintain
homeostasis of electrolyte concentrations and blood pressure. Chloride ion directly binds …

Transcriptomic responses to location learning by honeybee dancers are partly mirrored in the brains of dance-followers

F Manfredini, Y Wurm, S Sumner… - Proceedings of the …, 2023 - royalsocietypublishing.org
The waggle dances of honeybees are a strikingly complex form of animal communication
that underlie the collective foraging behaviour of colonies. The mechanisms by which bees …

[HTML][HTML] Neuronal activity disrupts myelinated axon integrity in the absence of NKCC1b

KLH Marshall-Phelps, L Kegel, M Baraban… - Journal of Cell …, 2020 - rupress.org
Through a genetic screen in zebrafish, we identified a mutant with disruption to myelin in
both the CNS and PNS caused by a mutation in a previously uncharacterized gene …

Chloride oscillation in pacemaker neurons regulates circadian rhythms through a chloride-sensing WNK kinase signaling cascade

JN Schellinger, Q Sun, JM Pleinis, SW An, J Hu… - Current Biology, 2022 - cell.com
Central pacemaker neurons regulate circadian rhythms and undergo diurnal variation in
electrical activity in mammals and flies. 1, 2 Circadian variation in the intracellular chloride …

Unanticipated domain requirements for Drosophila Wnk kinase in vivo

P Yarikipati, S Jonusaite, JM Pleinis… - PLoS …, 2023 - journals.plos.org
WNK (With no Lysine [K]) kinases have critical roles in the maintenance of ion homeostasis
and the regulation of cell volume. Their overactivation leads to pseudohypoaldosteronism …

Serotonergic modulation of visual neurons in Drosophila melanogaster

MM Sampson, KM Myers Gschweng… - PLoS …, 2020 - journals.plos.org
Sensory systems rely on neuromodulators, such as serotonin, to provide flexibility for
information processing as stimuli vary, such as light intensity throughout the day …

First Insights into Body Localization of an Osmoregulation-Related Cotransporter in Estuarine Annelids

S Mucciolo, A Desiderato, M Mastrodonato, P Lana… - Biology, 2024 - mdpi.com
Simple Summary The study aimed to confirm the presence of the Na+-K+-2Cl− cotransporter
(NKCC) in annelids, a membrane transporter crucial for cell volume regulation, which had …

SIK3 suppresses neuronal hyperexcitability by regulating the glial capacity to buffer K+ and water

H Li, A Russo, A DiAntonio - Journal of Cell Biology, 2019 - rupress.org
Glial regulation of extracellular potassium (K+) helps to maintain appropriate levels of
neuronal excitability. While channels and transporters mediating K+ and water transport are …

WNKs are potassium-sensitive kinases

JSP Zhang, DE Morrison, JN Schellinger, LK Jackson… - journals.physiology.org
ABSTRACT WNK (With No Lysine (K)) kinases regulate epithelial ion transport in the kidney
to maintain homeostasis of electrolyte concentrations and blood pressure. Chloride ion …