Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a
fundamental mechanism conserved from yeast to humans that regulates mitochondrial …

Myocardial infarction (MI) is the irreversible death of cardiomyocyte secondary to prolonged
lack of oxygen or fresh blood supply. Historically considered as merely cardiomyocyte …

Red blood cells (RBCs) are essential for aerobic respiration through delivery of oxygen to
distant tissues. However, RBCs are currently considered immunologically inert, and few, if …

The cardinal stages of macroautophagy are driven by core autophagy‐related (ATG)
proteins, whose ablation largely abolishes intracellular turnover. Disrupting ATG genes is …

Macroautophagy/autophagy is an evolutionarily conserved cellular degradation process that
targets cytoplasmic materials including cytosol, macromolecules and unwanted organelles …

Mitochondria and peroxisomes are closely related metabolic organelles, both in terms of
origin and in terms of function. Mitochondria and peroxisomes can also be turned over by …

Across all branches of the immune system, the process of autophagy is fundamentally
important in cellular development, function and homeostasis. Strikingly, this evolutionarily …

During cell division, it is critical to properly partition functional sets of organelles to each
daughter cell. The partitioning of mitochondria shares some common features with that of …

Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms …

Significance: Autophagy is a highly conserved eukaryotic cellular recycling process.
Through the degradation of cytoplasmic organelles, proteins, and macromolecules, and the …