Inhibitory immune checkpoint blockade has been one of the most significant advances in
anticancer therapy of the past decade. Research so far has largely focused on improving …

The signaling lymphocyte activation molecule (SLAM)-associated protein, SAP, was first
identified as the protein affected in most cases of X-linked lymphoproliferative (XLP) …

Cancer cells elude anti-tumour immunity through multiple mechanisms, including
upregulated expression of ligands for inhibitory immune checkpoint receptors,. Phagocytosis …

Immunotherapy using immune checkpoint inhibitors (ICIs) induces durable responses in
many metastatic cancers. Metastatic uveal melanoma (mUM), typically occurring in the liver …

CD4 T cell help is critical for the generation and maintenance of germinal centers (GCs), and
T follicular helper (T FH) cells are the CD4 T cell subset required for this process. Signaling …

CD4+ T cells deficient in signaling lymphocyte activation molecule (SLAM)-associated
protein (SAP) exhibit a selective impairment in adhesion to antigen-presenting B cells but …

Inbred laboratory mouse strains are highly divergent in their immune response patterns as a
result of genetic mutations and polymorphisms. The generation of genetically engineered …

CD48, a member of the signaling lymphocyte activation molecule family, participates in
adhesion and activation of immune cells. Although constitutively expressed on most …

Chimeric antigen receptors (CARs) are fusion proteins that contain antigen-recognition
domains and T cell signaling domains. Signaling lymphocytic-activation molecule F7 …

Although it is a widely studied psychiatric syndrome, major depressive disorder remains a
poorly understood illness, especially with regard to the disconnect between treatment …