Transition-metal-catalyzed, coordination-assisted C (sp3)–H functionalization has
revolutionized synthetic planning over the past few decades as the use of these directing …

Conspectus The functionalization of unactivated carbon–hydrogen bonds is a transformative
strategy for the rapid construction of molecular complexity given the ubiquitous presence of …

Among numerous solvents available for chemical transformations, 1, 1, 1, 3, 3, 3-hexafluoro-
2-propanol (popularly known as HFIP) has attracted enough attention of the scientific …

Catalyst-controlled site-selective activation of β-and γ-methylene carbon-hydrogen (C–H)
bonds of free carboxylic acids is a long-standing challenge. Here we show that, with a pair of …

Conspectus Enolate alkylation and conjugate addition into an α, β-unsaturated system have
served as long-standing strategic disconnections for the installation of α-or β-substituents on …

With the large number of Pd (II)-catalyzed C–H activation reactions of native substrates
developed in the past decade, the development of catalysts to enable the use of green …

Reactions that enable selective functionalization of strong aliphatic C–H bonds open new
synthetic paths to rapidly increase molecular complexity and expand chemical space …

Selective oxidation of the γ-C–H bonds from abundant amine feedstocks via palladium
catalysis is a valuable transformation in synthesis and medicinal chemistry. Despite …

Ligand-enabled Pd-catalyzed regioselective α, β-dehydrogenation of carbonyl compounds
via β-methylene C–H activation has recently emerged as a promising transformation …

The achievement of sufficient substrate–metal catalyst affinity is a fundamental challenge for
the development of synthetically useful C–H activation reactions of weakly coordinating …