The epigenetic profile of germ cells, which is defined by modifications of DNA and
chromatin, changes dynamically during their development. Many of the changes are …

The regulated migration of cells is essential for development and tissue homeostasis, and
aberrant cell migration can lead to an impaired immune response and the progression of …

Histone methylation regulates chromatin structure, transcription, and epigenetic state of the
cell. Histone methylation is dynamically regulated by histone methylases and demethylases …

Although genetics has an essential role in defining the development, morphology, and
physiology of an organism, epigenetic mechanisms have an essential role in modulating …

Genetic and epigenetic mechanisms regulate the transition from the totipotent zygote to
pluripotent primitive ectoderm cells in the inner cell mass of mouse blastocysts. These …

Induction of mouse germ cells occurs from the proximal epiblast at around embryonic day
(E) 7.0. These germ cells then migrate to, and enter the gonads at about E10. 5 after which …

Organisms can change their physiological/behavioural traits to adapt and survive in
changed environments. However, whether these acquired traits can be inherited across …

We previously reported that primordial germ cells (PGCs) in mice erase genome-wide DNA
methylation and histone H3 lysine9 dimethylation (H3K9me2), and instead acquire high …

Germ cells are the special cells in the body that undergo meiosis to generate gametes and
subsequently entire new organisms after fertilization, a process that continues generation …

Epigenetic information undergoes extensive reprogramming in the germline between
generations. This reprogramming may be essential to establish a developmental ground …