Review of synthesis and various biological activities of spiro heterocyclic compounds comprising oxindole and pyrrolidine moities
P Saraswat, G Jeyabalan, MZ Hassan… - Synthetic …, 2016 - Taylor & Francis
Spirocyclic compounds isolated from plant and animal origins have important applications in
medicinal chemistry. Spiro compounds having cyclic structures fused at a central carbon are …
medicinal chemistry. Spiro compounds having cyclic structures fused at a central carbon are …
The application of isatin-based multicomponent-reactions in the quest for new bioactive and druglike molecules
Oxindole derivatives are known for their great interest in the field of Medicinal Chemistry, as
they display vast biological activities. Recent efforts concerning the preparation of oxindole …
they display vast biological activities. Recent efforts concerning the preparation of oxindole …
Multifunctional derivatives of Spiropyrrolidine tethered Indeno-Quinoxaline heterocyclic hybrids as potent antimicrobial, antioxidant and antidiabetic agents: design …
To combat emerging antimicrobial-resistant microbes, there is an urgent need to develop
new antimicrobials with better therapeutic profiles. For this, a series of 13 new …
new antimicrobials with better therapeutic profiles. For this, a series of 13 new …
Synthesis of novel bis (spirocyclic-2-oxindole)-tethered 10b-azachrysene or 10a-azaphenanthrene systems via a Hantzsch-like reaction
AM Abdelmoniem, IA Abdelhamid, AHM Elwahy… - Tetrahedron, 2024 - Elsevier
The effective synthesis of bis (spirocyclic-2-oxindole) tethered to 10b-azachrysene or 10a-
azaphenanthrene moieties via the Hantzsch-like reaction of phenylenebis (methylene)) bis …
azaphenanthrene moieties via the Hantzsch-like reaction of phenylenebis (methylene)) bis …
Recent synthetic strategies toward the synthesis of spirocyclic compounds comprising six-membered carbocyclic/heterocyclic ring systems
Spirocyclic compounds fascinate the synthetic chemists due to their privileged ring system
and efficacy in drug discovery. Many natural compounds comprise spirocyclic moiety in their …
and efficacy in drug discovery. Many natural compounds comprise spirocyclic moiety in their …
EF24, a schistosomicidal curcumin analog: Insights from its synthesis and phenotypic, biochemical and cytotoxic activities
FR Badoco, LAL Paula, RP Orenha… - Chemico-Biological …, 2022 - Elsevier
Praziquantel (PZQ) is the only drug available for community-based control programs which
aim to reduce the prevalence and morbidity associated with schistosomiasis. Here, we …
aim to reduce the prevalence and morbidity associated with schistosomiasis. Here, we …
Advances in spirocyclic hybrids: chemistry and medicinal actions
M Benabdallah, O Talhi, F Nouali… - Current Medicinal …, 2018 - ingentaconnect.com
The present review deals with the progress in medicinal chemistry of spirocyclic compounds,
a wider class of natural and synthetic organic molecules, defined as a hybrid of two …
a wider class of natural and synthetic organic molecules, defined as a hybrid of two …
[HTML][HTML] Novel Spiro-pyrrolizidine-Oxindole and Spiropyrrolidine-Oxindoles: Green synthesis under Classical, Ultrasonic, and microwave conditions and Molecular …
DF Katowah, HME Hassaneen, TA Farghaly - Arabian Journal of Chemistry, 2022 - Elsevier
Novel spiropyrrolizine/pyrrolidineoxindole moieties were synthesized chemo-, and regio-
selectively in high yields from knoevenagel reaction of bis [arylmethylidene] piperidin-4 …
selectively in high yields from knoevenagel reaction of bis [arylmethylidene] piperidin-4 …
Synthesis of new spirooxindole derivatives through 1, 3-dipolar cycloaddition of azomethine ylides and their antitubercular activity
F Rouatbi, M Askri, F Nana, G Kirsch, D Sriram… - Tetrahedron …, 2016 - Elsevier
Non-stabilized azomethine ylides, generated in situ from isatin derivatives and l-proline,
have been reacted with (E, E)-1, 3-bis (arylidene) indan-2-ones as dipolarophiles in a 1, 3 …
have been reacted with (E, E)-1, 3-bis (arylidene) indan-2-ones as dipolarophiles in a 1, 3 …
Hybridization of curcumin analogues with cinnamic acid derivatives as multi-target agents against Alzheimer's disease targets
E Chainoglou, A Siskos, E Pontiki, D Hadjipavlou-Litina - Molecules, 2020 - mdpi.com
The synthesis of the new hybrids followed a hybridization with the aid of hydroxy-
benzotriazole (HOBT) and 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDCI. HCL) in …
benzotriazole (HOBT) and 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDCI. HCL) in …