The modification of nuclear, mitochondrial, and cytosolic proteins by O-linked βN-
acetylglucosamine (O-GlcNAc) has emerged as a dynamic and essential post-translational …

The sorting and trafficking of lipids between organelles gives rise to a dichotomy of bulk
membrane properties between organelles of the secretory and endolysosome networks …

The Golgi apparatus is at the center of protein processing and trafficking in normal cells.
Under pathological conditions, such as in cancer, aberrant Golgi dynamics alter the tumor …

Sphingomyelin plays a key role in cellular cholesterol homeostasis by binding to and
sequestering cholesterol in the plasma membrane. We discovered that synthesis of very …

At first glance, the biological function of globoside (Gb) clusters appears to be that of
glycosphingolipid (GSL) receptors for bacterial toxins that mediate host-pathogen …

Metabolic pathways are complex and intertwined. Deficiencies in one or more enzymes in a
given pathway are directly linked with genetic diseases, most of them having devastating …

Background Macrophages are the predominant immune cells in the human lung and play a
central role in airway inflammation, including asthma and chronic obstructive pulmonary …

The Golgi apparatus is an essential cellular organelle that mediates homeostatic functions,
including vesicle trafficking and the post-translational modification of macromolecules. Its …

Glycosphingolipids (GSLs) are a diverse group of membrane components occurring mainly
on the surfaces of mammalian cells. They and their metabolites have a role in intercellular …

Glycosylation of proteins and lipids is of fundamental importance in multicellular eukaryotes.
The vast diversity of glycan structures observed is generated in the Golgi apparatus by the …