Curcumin analogues and derivatives with anti-proliferative and anti-inflammatory activity: Structural characteristics and molecular targets
E Chainoglou, D Hadjipavlou-Litina - Expert opinion on drug …, 2019 - Taylor & Francis
ABSTRACT Introduction: Curcumin (Diferuloylmethane) is a natural phenolic compound,
which belongs to the curcuminoid family, presenting pleiotropic activity and low …
which belongs to the curcuminoid family, presenting pleiotropic activity and low …
An overview of structure–activity relationship studies of curcumin analogs as antioxidant and anti-inflammatory agents
Curcumin, extracted mainly from Curcuma longa rhizomes, has been reported to possess
potent anti-inflammatory and anti-oxidant activities. Although safe at higher doses and …
potent anti-inflammatory and anti-oxidant activities. Although safe at higher doses and …
Molecular insights into the interaction of RONS and Thieno [3, 2-c] pyran analogs with SIRT6/COX-2: A molecular dynamics study
SIRT6 and COX-2 are oncogenes target that promote the expression of proinflammatory and
pro-survival proteins through a signaling pathway, which leads to increased survival and …
pro-survival proteins through a signaling pathway, which leads to increased survival and …
Immunosuppressive effects of natural α, β-unsaturated carbonyl-based compounds, and their analogs and derivatives, on immune cells: a review
The immune system is complex and pervasive as it functions to prevent or limit infections in
the human body. In a healthy organism, the immune system and the redox balance of …
the human body. In a healthy organism, the immune system and the redox balance of …
Erica multiflora extract rich in quercetin-3-O-glucoside and kaempferol-3-O-glucoside alleviates high fat and fructose diet-induced fatty liver disease by modulating …
R Khlifi, Z Dhaouefi, IB Toumia, A Lahmar… - The Journal of …, 2020 - Elsevier
The wide morbidity of obesity has heightened interest in providing natural and safe
compounds to maintain optimal health. The present study was designed to determine the …
compounds to maintain optimal health. The present study was designed to determine the …
Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
Curcumin is a small organic molecule with pleiotropic biological activities. However, its
multiple structural-pharmacokinetic challenges prevent its development into a clinical drug …
multiple structural-pharmacokinetic challenges prevent its development into a clinical drug …
Investigation of anti-cancer activity of newly synthesized 2, 4-pentadien-1-one derivative containing benzofuran in human lung and colon cancer cells
E Erturk, G Tuna, D Coskun… - Eurasian Journal of …, 2023 - search.proquest.com
Abstract [LANGUAGE=" English"] Objectives: A member of the flavonoid family, chalcones
are natural compounds known to have anticancer effects. Chalcones and their synthetic …
are natural compounds known to have anticancer effects. Chalcones and their synthetic …
Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human …
The syntheses and bioactivities of symmetrical curcumin and its analogues have been the
subject of interest by many medicinal chemists and pharmacologists over the years. To …
subject of interest by many medicinal chemists and pharmacologists over the years. To …
Diarylpentadienone derivatives (curcumin analogues): Synthesis and anti-inflammatory activity
ZS Wang, LZ Chen, HP Zhou, XH Liu… - Bioorganic & Medicinal …, 2017 - Elsevier
A series of new (2E, 4E)-1-(substitutedphenyl)-5-(substitutedphenyl) penta-2, 4-dien-1-one
derivatives were designed and synthesized. Compounds 3i, 3k were determined by X-ray …
derivatives were designed and synthesized. Compounds 3i, 3k were determined by X-ray …
Bioactive Diarylpentanoids: Insights into the Biological Effects beyond Antitumor Activity and Structure–Activity Relationships
J Moreira, L Saraiva, MM Pinto, H Cidade - Molecules, 2022 - mdpi.com
Diarylpentanoids, a class of natural products and their synthetic analogs which are
structurally related to chalcones, have gained increasing attention due to their wide array of …
structurally related to chalcones, have gained increasing attention due to their wide array of …