The tumor microenvironment is crucial for the growth of cancer cells, triggering particular
biochemical and physiological changes, which frequently influence the outcome of …

Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins
that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide …

A new series of imidazolyl hydrazone derivatives IA (1-12) were prepared from a
condensation reaction between indoline-2, 3-dione (isatin) and 2 …

The hydrophobic and the hydrophilic rims in the active site of human carbonic anhydrase IX
(hCA IX) which as well contains a zinc ion as part of the catalytic core, were simultaneously …

What is known and objective The main objective of this review is to highlight the most
relevant studies since 1990 (to date) in the area of medicinal chemistry aspects to provide a …

Introduction Hypoxic tumors, unlike normal tissues, overexpress proteins involved in oxygen
sensing, metabolism, pH regulation, angiogenesis, immunological response, and other …

Coumarin is an important six-membered aromatic heterocyclic pharmacophore, widely
distributed in natural products and synthetic molecules. The versatile and unique features of …

As an important characteristic of tumor, acidic tumor microenvironment (TME) is closely
related to immune escape, invasion, migration and drug resistance of tumor. The acidity of …

Abstract Different 2, 4-thiazolidinedione-tethered coumarins 5a–b, 10a–n and 11a–d were
synthesised and evaluated for their inhibitory action against the cancer-associated h CAs IX …

The Carbonic anhydrase isoforms IX and XII play a significant role in regulating the
intracellular and extracellular pH in hypoxic tumours abetting the metastasis of solid …