In contrast to the major families of small molecules and antibodies, cyclic peptides, as a
family of synthesizable macromolecules, have distinct biochemical and therapeutic …

Peptides as a therapeutic modality attract much attention due to their synthetic accessibility,
high degree of specific binding, and the ability to target protein surfaces traditionally …

Our ever‐increasing understanding of biological systems is providing a range of exciting
novel biological targets, whose modulation may enable novel therapeutic options for many …

Many proteins exert their biological activities through small exposed surface regions called
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …

Drug discovery has traditionally focused on using libraries of small molecules to identify
therapeutic drugs, but new modalities, especially libraries of genetically encoded cyclic …

Rapid advancements in genomics have brought a better understanding of molecular
mechanisms for various pathologies and identified a number of highly attractive target …

Highlights•Non-antibody scaffold drugs are a promising new class of biologics drugs.•The
first candidate scaffolds are now moving into clinical development and practice.•Challenges …

Conspectus Cyclic peptides can bind to protein targets with high affinities and selectivities,
which makes them an attractive modality for the development of research reagents and …

The function of the fibrinolytic system was first identified to dissolve fibrin to maintain
vascular patency. Connections between the fibrinolytic system and many other physiological …

Highlights•PPIs that are dominated by a continuous epitope are amenable for inhibition.•A
significant share of PPIs contains such 'hot segments'.•Peptide-based inhibitors are obvious …