Epigenetic modifications are widely accepted as playing a critical role in the regulation of
gene expression and thereby contributing to the determination of the phenotype of …

Approximately 10%–15% of couples are infertile, and a male factor is involved in almost half
of these cases. This observation is due in part to defects in spermatogenesis, and the …

Along with many of the genome-wide transitions in chromatin composition throughout
spermatogenesis, epigenetic modifications on histone tails and DNA are continuously …

BACKGROUND In spite of tremendous efforts by a number of groups, the search for single
nucleotide polymorphisms (SNPs) strongly associated with male factor infertility by means of …

Background Azoospermia is the absence of a measurable level of spermatozoa in the
semen. It affects approximately 1% of all men, and the genetic basis of the majority of …

Mammalian spermatogenesis is a highly specialized differentiation process involving
precise regulatory mechanisms at the transcriptional, posttranscriptional, and translational …

Background Early liver development and the transcriptional transitions during
hepatogenesis are well characterized. However, gene expression changes during the late …

The hallmarks of premalignant lesions were first described in the 1970s, a time when
relatively little was known about the molecular underpinnings of cancer. Yet it was clear …

Semen analysis is usually the first step in the assessment of male fertility. Although analyzes
provide valuable information about male fertility, success of cytoplasmic sperm injection …

Background Goats were domesticated 10,500 years ago to supply humans with useful
resources. Since then, specialized breeds that are adapted to their local environment have …