Pathogens including viruses, bacteria, fungi, and parasites continue to shape our lives in
profound ways every day. As we have learned to live in parallel with pathogens, we have …

It has been amply constated that sugar ligand multivalency increases lectin-binding avidities
dramatically, thereby modulating the capacity of carbohydrates to participate in …

Treating a viral disease is no simple feat. Drug resistance, latent reservoirs in the body,
emerging novel viruses, and a frequent lack of specific treatments all complicate antiviral …

Well-defined, highly reactive poly (norbornenyl azlactone) s of controlled length (number-
average degree of polymerization DP n¯= 10 to 1,000) were made by ring-opening …

Glycosidases are ubiquitous enzymes involved in a diversity of key biological processes
such as energy uptake or cell wall degradation. The design of specific glycosidase inhibitors …

The first phosphorus dendrimers built on a cyclotriphosphazene core and decorated with six
or twelve monofluorocyclooctyne units were prepared. A simple stirring allowed the grafting …

Bacterial sialidases (SA) are validated drug targets expressed by common human
pathogens such as Streptococcus pneumoniae, Vibrio cholerae, or Clostridium perfringens …

A panel of divalent oseltamivir and guanidino oseltamivir analogues with esterification on
the carboxyl acid group as potent inhibitors of influenza virus neuraminidase was prepared …

In the absence of naturally available galactofuranose-specific lectin, we report herein the
bioengineering of Gal f NeoLect, from the first cloned wild-type galactofuranosidase …

Streptococcus pneumoniae is a pathogenic bacterium that contains the surface-bound
neuraminidase, NanA. NanA has two domains that interact with sialosides. It is hard to …