In this review, we comprehensively present the function of epigenetic regulations in normal
placental development as well as in a prominent disease of placental origin, preeclampsia …

Background An imbalance in the expression of vascular endothelial growth factor (VEGF)
and its receptor (VEGF-R) during pregnancy plays an important role in the pathogenesis of …

Epigenetic mechanisms, often defined as regulating gene activity independently of
underlying DNA sequence, are crucial for healthy development. The sum total of epigenetic …

Preeclampsia (PE) is a pregnancy-specific disorder, defined as new onset of maternal
hypertension and proteinuria after 20 weeks of gestation. Our earlier study has shown …

Background Preeclampsia (PE) is a heterogeneous, hypertensive disorder of pregnancy,
with no robust biomarkers or effective treatments. We hypothesized that this heterogeneity is …

Introduction Preeclampsia (PE) carries increased risks of cardiovascular-and metabolic
diseases in mothers and offspring during the life course. While the severe early-onset PE …

Background Diabetic retinopathy (DR), a specific neuron-vascular complication of diabetes,
is a major cause of vision loss among middle-aged people worldwide, and the number of …

Preeclampsia is a hypertensive disorder of pregnancy that affects 3–5% of all pregnancies.
There is evidence to suggest that epigenetic mechanisms, such as DNA methylation, play a …

Preeclampsia is a potentially fatal pregnancy disorder affecting millions of women around
the globe. Dysregulation in gene and protein expression within key biological pathways …

Placental health is a key component to a successful pregnancy. Placental insufficiency (PI),
inadequate nutrient delivery to the fetus, is associated with preeclampsia (PE), a maternal …