Irisin is a myokine derived from the cleavage of fibronectin type III domain-containing 5. Irisin
regulates mitochondrial energy, glucose metabolism, fatty acid oxidation, and fat browning …

Despite clinical and scientific advancements, heart failure is the major cause of morbidity
and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the …

Current methods to differentiate cardiomyocytes from human pluripotent stem cells (PSCs)
inadequately recapitulate complete development and result in PSC-derived cardiomyocytes …

Cardiovascular diseases (CVDs) are one of the leading causes of morbidity and mortality in
developed countries. CVDs are a group of disorders of the heart and blood vessels. They …

Cardiovascular disease is a leading cause of death worldwide, and thus there remains great
interest in regenerative approaches to treat heart failure. In the past 20 years, the field of …

Pluripotent stem cells (PSCs) can undergo unlimited self-renewal and can differentiate into
all the cell types present in our body, including cardiomyocytes. Therefore, PSCs can be an …

Mitochondria are specialized organelles, which serve as the “Power House” to generate
energy for maintaining heart function. These organelles contain various enzymes for the …

The mitochondrial protease Lonp1 is a multifunctional enzyme that regulates crucial
mitochondrial functions, including the degradation of oxidized proteins, folding of imported …

Mitochondria are the main site of intracellular synthesis of ATP, which provides energy for
various physiological activities of the cell. Cardiomyocytes have a high density of …

The WNT/β‐catenin pathway is a master regulator of cardiac development and growth, and
its activity is low in healthy adult hearts. However, even this low activity is essential for …