The role of progesterone receptors in breast cancer

Z Li, H Wei, S Li, P Wu, X Mao - Drug design, development and …, 2022 - Taylor & Francis
The progesterone receptor (PR) modulates estrogen receptors α (ERα) action in breast
cancer; it is an upregulated target gene of ER, and its expression is dependent on estrogen …

The divergent effects of ovarian steroid hormones in the MCF-7 model for Luminal A breast cancer: Mechanistic leads for therapy

NT Telang - International Journal of Molecular Sciences, 2022 - mdpi.com
The growth modulating effects of the ovarian steroid hormones 17β-estradiol (E2) and
progesterone (PRG) on endocrine-responsive target tissues are well established. In …

Progesterone receptor signaling promotes cancer associated fibroblast mediated tumorigenicity in ER+ breast cancer

CH Diep, A Spartz, TH Truong, AR Dwyer… - …, 2024 - academic.oup.com
Breast cancer progression involves intricate interactions between cancer cells and the tumor
microenvironment (TME). This study elucidates the critical role of progesterone receptor …

Progesterone receptors in normal breast development and breast cancer

S Giulianelli, CA Lamb, C Lanari - Essays in Biochemistry, 2021 - portlandpress.com
Progesterone receptors (PR) play a pivotal role in many female reproductive tissues such as
the uterus, the ovary, and the mammary gland (MG). Moreover, PR play a key role in breast …

Dynamic interplay of nuclear receptors in tumor cell plasticity and drug resistance: Shifting gears in malignant transformations and applications in cancer therapeutics

B BharathwajChetty, A Sajeev, R Vishwa… - Cancer and Metastasis …, 2024 - Springer
Recent advances have brought forth the complex interplay between tumor cell plasticity and
its consequential impact on drug resistance and tumor recurrence, both of which are critical …

Hormone Metabolites and Herbal Bioactive Agents: Potential Drug Candidates for the Luminal A Breast Cancer subtype

NT Telang - Medical Research Archives, 2024 - esmed.org
Background: Hormone receptor positive, human epidermal growth factor receptor negative
Luminal A breast cancer subtype responds to targeted endocrine therapy, signal …

[PDF][PDF] MiR-574-5p dysregulation in metastatic breast cancer through cell migration

O Doğan, Ş Linton, C Öztürk, O Murat - 2024 - ajbm.net
Breast cancer is the most frequently diagnosed malignancy among women worldwide. The
occurrence rate of metastasis is also increased. It's reported that 20–30% of breast cancer …