Singlet molecular oxygen reactions with nucleic acids, lipids, and proteins

P Di Mascio, GR Martinez, S Miyamoto… - Chemical …, 2019 - ACS Publications
Singlet oxygen (1O2) is a biologically relevant reactive oxygen species capable of efficiently
reacting with cellular constituents. The resulting oxidatively generated damage to nucleic …

Formation of UV-induced DNA damage contributing to skin cancer development

J Cadet, T Douki - Photochemical & Photobiological Sciences, 2018 - pubs.rsc.org
UV-induced DNA damage plays a key role in the initiation phase of skin cancer. When left
unrepaired or when damaged cells are not eliminated by apoptosis, DNA lesions express …

DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation

J Cadet, JR Wagner - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
Emphasis has been placed in this article dedicated to DNA damage on recent aspects of the
formation and measurement of oxidatively generated damage in cellular DNA in order to …

Photodynamic efficiency: from molecular photochemistry to cell death

IOL Bacellar, TM Tsubone, C Pavani… - International journal of …, 2015 - mdpi.com
Photodynamic therapy (PDT) is a clinical modality used to treat cancer and infectious
diseases. The main agent is the photosensitizer (PS), which is excited by light and converted …

Targeted and persistent 8-oxoguanine base damage at telomeres promotes telomere loss and crisis

E Fouquerel, RP Barnes, S Uttam, SC Watkins… - Molecular cell, 2019 - cell.com
Telomeres are essential for genome stability. Oxidative stress caused by excess reactive
oxygen species (ROS) accelerates telomere shortening. Although telomeres are …

Photosensitization reactions of biomolecules: definition, targets and mechanisms

MS Baptista, J Cadet, A Greer… - Photochemistry and …, 2021 - Wiley Online Library
Photosensitization reactions have been demonstrated to be largely responsible for the
deleterious biological effects of UV and visible radiation, as well as for the curative actions of …

Formation and repair of oxidatively generated damage in cellular DNA

J Cadet, KJA Davies, MHG Medeiros… - Free Radical Biology …, 2017 - Elsevier
In this review article, emphasis is placed on the critical survey of available data concerning
modified nucleobase and 2-deoxyribose products that have been identified in cellular DNA …

Polycationic synergistic antibacterial agents with multiple functional components for efficient anti‐infective therapy

Y Zhu, C Xu, N Zhang, X Ding, B Yu… - Advanced Functional …, 2018 - Wiley Online Library
Multifunctional antibacterial photodynamic therapy is a promising method to combat regular
and multidrug‐resistant bacteria. In this work, eosin Y (EY)‐based antibacterial polycations …

Significance of singlet oxygen molecule in pathologies

K Murotomi, A Umeno, M Shichiri, M Tanito… - International Journal of …, 2023 - mdpi.com
Reactive oxygen species, including singlet oxygen, play an important role in the onset and
progression of disease, as well as in aging. Singlet oxygen can be formed non …

Oxidatively Generated Damage to Cellular DNA by UVB and UVA Radiation,

J Cadet, T Douki, JL Ravanat - Photochemistry and …, 2015 - Wiley Online Library
This review article focuses on a critical survey of the main available information on the UVB
and UVA oxidative reactions to cellular DNA as the result of direct interactions of UV …