Angiogenesis, the process of new blood vessels formation from existing vasculature, plays a
vital role in development, wound healing, and various pathophysiological conditions. In …

Since the invention of cardiopulmonary bypass, cardioprotective strategies have been
investigated to mitigate ischemic injury to the heart during aortic cross-clamping and …

Introduction: Patients with advanced coronary artery disease (CAD) who are not eligible for
stenting or surgical bypass procedures have limited treatment options. Extracellular vesicles …

Objective Limited treatments exist for nonoperative chronic coronary artery disease.
Previously, our laboratory has investigated extracellular vesicle (EV) therapy as a potential …

Despite the overwhelming use of cellularized therapeutics in cardiac regenerative
engineering, approaches to biomanufacture engineered cardiac tissues (ECTs) at clinical …

The past several decades have borne witness to several breakthroughs and paradigm shifts
within the field of cardiovascular medicine, but one component that has remained constant …

Acute myocardial infarction (MI) is a sudden, severe cardiac ischemic event that results in
the death of up to one billion cardiomyocytes (CMs) and subsequent decrease in cardiac …

Background Coronary artery disease remains a leading cause of death worldwide. Bone
mesenchymal stem cell–derived extracellular vesicles (EVs) have shown promise in the …

Objective: To test the efficacy of metformin (MET) during the induction of coronary ischemia
on myocardial performance in a large animal model of coronary artery disease (CAD) and …