The Protective Effects of Nutraceutical Components in Methotrexate-Induced Toxicity Models—An Overview
There are multiple concerns associated with methotrexate (MTX), widely recognized for anti-
neoplastic and anti-inflammatory effects in life-threatening disease conditions, ie, acute …
neoplastic and anti-inflammatory effects in life-threatening disease conditions, ie, acute …
[HTML][HTML] The impact of gallic acid on the methotrexate-induced kidney damage in rats
Prolonged use of an antineoplastic agent methotrexate (MTX), can cause numerous side
effects such as nephrotoxicity. The aim of this study was to examine the effects of MTX on …
effects such as nephrotoxicity. The aim of this study was to examine the effects of MTX on …
Ameliorative effect of gallic acid on cisplatin-induced ovarian toxicity in rats
E Ayazoglu Demir, A Mentese, A Livaoglu… - Drug and chemical …, 2023 - Taylor & Francis
The aim of the present study was to evaluate the protective effect of gallic acid (GA) against
cisplatin (CDDP)-induced ovarian toxicity, for the first time. The ovarian damage was …
cisplatin (CDDP)-induced ovarian toxicity, for the first time. The ovarian damage was …
Methotrexate induced hepatotoxicity and antioxidants
AU Akman - Sabuncuoglu Serefeddin Health Sciences, 2021 - dergipark.org.tr
Methotrexate (MTX) is an antifolate and antimetabolite group chemotherapeutic agent that
has been used in the treatment of many diseases since 1948. MTX treatment has various …
has been used in the treatment of many diseases since 1948. MTX treatment has various …
The renoprotective effects of gallic acid on cisplatin-induced nephrotoxicity through anti-apoptosis, anti-inflammatory effects, and downregulation of lncRNA TUG1
Cisplatin, an antineoplastic drug used in cancer therapy,-induced nephrotoxicity mediated
by the production of reactive oxygen species (ROS). Gallic acid (GA) is identified as an …
by the production of reactive oxygen species (ROS). Gallic acid (GA) is identified as an …
Whey protein concentrate ameliorates the methotrexate-induced liver and kidney damage
E Tufan, GG Sivas, B Gürel-Gökmen… - British Journal of …, 2023 - cambridge.org
Methotrexate (MTX) is a cytotoxic immunosuppressant that is widely used in the treatment of
tumours, rheumatoid arthritis and psoriasis. This study aims to evaluate the effects of whey …
tumours, rheumatoid arthritis and psoriasis. This study aims to evaluate the effects of whey …
[HTML][HTML] Protective effect of gallic acid against thioacetamide-induced metabolic dysfunction of lipids in hepatic and renal toxicity
Background Gallic acid (GA) has significant antioxidant bioactivity and can prevent diet-
induced hypertriglyceridemia by reducing adipocytes. GA was also observed to enhance …
induced hypertriglyceridemia by reducing adipocytes. GA was also observed to enhance …
Beneficial effects of silymarin and naringin against methotrexate-induced hepatotoxicity in rats.
Hepatotoxicity occurs as a result of the complications of methotrexate (MTX) therapy, which
is a chemotherapeutic drug. Silymarin (SLY) and naringin (NRG) are bioflavonoids possess …
is a chemotherapeutic drug. Silymarin (SLY) and naringin (NRG) are bioflavonoids possess …
Nobiletin alleviates methotrexate-induced hepatorenal toxicity in rats
We investigated the possible ameliorative effects of nobiletin (NBL) against methotrexate
(MTX)-induced hepatorenal toxicity in rats. Twenty-eight Wistar albino rats were randomly …
(MTX)-induced hepatorenal toxicity in rats. Twenty-eight Wistar albino rats were randomly …
Rutin attenuates methotrexate-induced hepatic oxidative stress in rats
S Türk, F Kazak, P Peker… - … Veteriner Bilimleri Dergisi, 2021 - dergipark.org.tr
This study aimed to assess the antioxidant effects of rutin on methotrexate-induced hepatic
oxidative stress. Wistar Albino rats (n= 24) were separated into 4 groups: control group (C); …
oxidative stress. Wistar Albino rats (n= 24) were separated into 4 groups: control group (C); …