Experimental modelling of human disorders enables the definition of the cellular and
molecular mechanisms underlying diseases and the development of therapies for treating …

In mammals, the expression of a subset of microRNA (miRNA) genes is governed by
genomic imprinting, an epigenetic mechanism that confers monoallelic expression in a …

Diploidy is a fundamental genetic feature in mammals, in which haploid cells normally arise
only as post-meiotic germ cells that serve to ensure a diploid genome upon fertilization …

Parental imprinting is a form of epigenetic regulation that results in parent-of-origin
differential gene expression. To study Prader-Willi syndrome (PWS), a developmental …

The parent-specific monoallelic expression of imprinted genes is controlled by DNA
methylation marks that are established differentially in the germline. Perturbation of these …

Genomic imprinting plays an important role in growth and development. Loss of imprinting
(LOI) has been found in cancer, yet systematic studies are impeded by data-analytical …

MicroRNA (miRNA) acts as a critical regulator of gene expression at post-transcriptional and
occasionally transcriptional levels in plants. Identification of reliable miRNA genes …

Oral squamous cell carcinoma (OSCC) is among the leading causes of cancer-associated
deaths worldwide. Family members in miR-371/372/373 miRNA cluster, which is localized at …

Genomic imprinting is an epigenetic mechanism that results in parent-of-origin monoallelic
expression of specific genes, which precludes uniparental development and underlies …

Hepatocellular carcinoma (HCC) is one of the most aggressive types of cancer and is
among the leading causes of cancer-related mortality worldwide. Although the dysregulation …