Single Cell mass spectrometry: Towards quantification of small molecules in individual cells

Y Lan, Z Zou, Z Yang - TrAC Trends in Analytical Chemistry, 2024 - Elsevier
Studying cell heterogeneity can provide a deeper understanding of biological activities, but
appropriate studies cannot be performed using traditional bulk analysis methods. The …

MetaPhenotype: A Transferable Meta-Learning Model for Single-Cell Mass Spectrometry-Based Cell Phenotype Prediction Using Limited Number of Cells

S Yao, TD Nguyen, Y Lan, W Yang, D Chen… - Analytical …, 2024 - ACS Publications
Single-cell mass spectrometry (SCMS) is an emerging tool for studying cell heterogeneity
according to variation of molecular species in single cells. Although it has become …

Targeted Quantification of Glutathione/Arginine Redox Metabolism Based on a Novel Paired Mass Spectrometry Probe Approach for the Functional Assessment of …

ZJ Zhong, J Ling, ZP Yao, LF Liu, JY Zheng… - Analytical …, 2024 - ACS Publications
Glutathione (GSH) redox control and arginine metabolism are critical in regulating the
physiological response to injury and oxidative stress. Quantification assessment of the …

Sonochemical preparation of nanocomposites of gold nanoparticles and graphene oxide for selective electrochemical sensing of nitric oxide

Q Zhang, TK Sari, F Takahashi, H Tatsumi… - Chemistry Letters, 2024 - academic.oup.com
In this study, gold nanoparticles and graphene oxide nanocomposite-modified electrodes
were prepared by the sonochemical method. We evaluated their electrocatalytic activity …

Exploring Single-probe Single-Cell Mass Spectrometry: Current Trends and Future Directions

D Bhusal, S Munige, Z Peng, Z Yang - 2024 - chemrxiv.org
The Single-probe is a multifunctional device that can be coupled to mass spectrometry (MS)
for molecular analysis of microscale samples, such as single cells, tissue slices, and …

Developing Cell Quenching Method to Facilitate Single Cell Mass Spectrometry Metabolomics Studies

SW Munige, D Bhusal, Z Peng, D Chen, Z Yang - 2024 - chemrxiv.org
Single-cell mass spectrometry (SCMS) has emerged as a powerful tool for analyzing
metabolites in individual cells, including live cells. However, cell metabolites have rapid …

Mass Spectrometry as a Bioanalytical Tool for Quantitative Proteomic and Small Molecule Analysis: Investigating Cell-Cell Interactions and Body Fluids

Z Peng - 2024 - search.proquest.com
Chemoresistance is a major failure of chemotherapy. Understanding the mechanisms
behind chemoresistance will benefit the development of anticancer drugs and clinical …