Now 30 years old, the chronic mild stress (CMS) model of depression has been used in>
1300 published studies, with a year-on-year increase rising to> 200 papers in 2015. Data …

Sustained anticipatory anxiety is central to Generalized Anxiety Disorder (GAD). During
anticipatory anxiety, phasic threat responding appears to be mediated by the amygdala …

We show that in an animal model of anxiety the overall excitation, particularly in the
infralimbic region of the medial prefrontal cortex (IL), is increased and that the activity ratio …

Targeting neuropeptide systems is important for future advancements in treatment of
neurological and psychiatric illnesses. However, many of the peptides and their analogs do …

Growing research indicates oxytocin may be involved in relieving anxiety and attenuating
the rewarding effects of psychostimulants. This study investigated the effects of subchronic …

Background Psycho-emotional well-being is essential for living a life of satisfaction and
fulfillment. However, depression and anxiety have become the leading mental health issues …

Post-traumatic stress disorder (PTSD) is a psychiatric disorder that afflicts many individuals.
However, its molecular and cellular mechanisms remain largely unexplored. Here, we found …

Adverse childhood experiences (ACEs) are recognised as precursors to numerous physical
and mental health challenges. However, research on their impact on inhibitory control and …

Background and purpose: The central nucleus of the amygdala (CeA) is one of the nuclei
involved in the reward system. The aim of the current study was to investigate the electrical …

RICH2 knockout (RICH2 KO) mice exhibit neophobia in the novel object test. To gain further
insight into their anxiety-related phenotype, we subjected these mice to additional …