DNA topoisomerases have an essential role in resolving topological problems that arise due
to the double-helical structure of DNA. They can recognise DNA topology and catalyse …

Topoisomerases, common targets for anti-cancer therapeutics, are crucial enzymes for DNA
replication, transcription, and many other aspects of DNA metabolism. The potential anti …

DNA gyrase is a type II topoisomerase with the unique capacity to introduce negative
supercoiling in DNA. In bacteria, DNA gyrase has an essential role in the homeostatic …

Magnetic tweezers are a single-molecule force and torque spectroscopy technique that
enable the mechanical interrogation in vitro of biomolecules, such as nucleic acids and …

Type II topoisomerases are ubiquitous enzymes that play a pivotal role in modulating the
topological configuration of double-stranded DNA. These topoisomerases are required for …

Type II DNA topoisomerases regulate topology by double-stranded DNA cleavage and
ligation. The TopoVI family of DNA topoisomerase, first identified and biochemically …

DNA topoisomerases (topos) are major targets for antimicrobial and chemotherapeutic
drugs due to their fundamental roles in regulating DNA topology. Type II topos are essential …

Topoisomerases regulate the topological state of cellular genomes to prevent impediments
to vital cellular processes, including replication and transcription from suboptimal …

Fungal infections represent a growing public health problem, mainly stemming from two
phenomena. Firstly, certain diseases (eg, AIDS and COVID-19) have emerged that weaken …

During DNA replication, the replisome must rotate relative to the DNA substrate, generating
supercoiling that must be partitioned in front of or behind the replisome. Supercoiling …