The placenta is essential for normal in utero development in mammals. In humans, defective
placental formation underpins common pregnancy disorders such as pre-eclampsia and …

In this review, we comprehensively present the function of epigenetic regulations in normal
placental development as well as in a prominent disease of placental origin, preeclampsia …

Widespread changes to DNA methylation and chromatin are well documented in cancer, but
the fate of higher-order chromosomal structure remains obscure. Here we integrated …

Recurrent pregnancy loss (RPL) is a common and severe pathological pregnancy, whose
pathogenesis is not fully understood. With the development of epigenetics, the study of DNA …

The human placenta and its specialized cytotrophoblasts rapidly develop, have a
compressed lifespan, govern pregnancy outcomes, and program the offspring's health …

The placenta is the interface between maternal and fetal circulations, integrating maternal
and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as …

Placenta-specific trophoblast and tumor cells exhibit many common characteristics.
Trophoblast cells invade maternal tissues while being tolerated by the maternal immune …

Tumor heterogeneity makes early diagnosis and effective treatment of colon
adenocarcinoma difficult. As an important regulator of gene expression, DNA methylation …

Background The placenta is essential for nutrient exchange and hormone production
between the mother and the developing fetus and serves as an invaluable model for …

The human placenta is exposed to major environmental changes towards the end of the first
trimester associated with full onset of the maternal arterial placental circulation. Changes …