Immune thrombocytopenia (ITP) is a complex autoimmune disease characterized by low
platelet counts. The pathogenesis of ITP remains unclear although both antibody-mediated …

Immune thrombocytopenia (ITP) is a rare autoimmune disease due to an abnormal T cell
response, notably supported by splenic T follicular helper cells, that stimulates the …

Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …

Intravenous immunoglobulin (IVIG) is a pooled preparation of normal IgG obtained from
several thousand healthy donors. It is widely used in the immunotherapy of a large number …

Immune thrombocytopenia (ITP) is an autoimmune disease defined by low platelet counts
which presents with an increased bleeding risk. Several genetic risk factors (eg …

Platelets, small anucleate cells circulating in the blood, are critical mediators in haemostasis
and thrombosis. Interestingly, recent studies demonstrated that platelets contain both pro …

Over the past decades, a wealth of information has been reported about the pathogenic
features of immune thrombocytopenia (ITP). To this day, however, it is unclear whether the …

Childhood immune thrombocytopenia (ITP) is a rare autoimmune bleeding disorder. Most
children recover within 6 to 12 months, but individual course is difficult to predict. We …

Background Immune checkpoint inhibitors, including antibodies against programmed death
1 (PD-1) and cytotoxic T-lymphocyte antigen 4 (CTLA-4), are being used with increasing …

Our previous clinical study showed that low-dose decitabine exhibited sustained responses
in nearly half of patients with refractory immune thrombocytopenia (ITP). The long-term …