Successful cell division requires the precise and timely coordination of chromosomal,
cytoskeletal and membrane trafficking events. These processes are regulated by the …

DNA damage is a key factor both in the evolution and treatment of cancer. Genomic
instability is a common feature of cancer cells, fuelling accumulation of oncogenic mutations …

Innate lymphoid cells (ILCs) are innate counterparts of adaptive T lymphocytes, contributing
to host defense, tissue repair, metabolic homeostasis, and inflammatory diseases. ILCs have …

The ataxia telangiectasia mutated and Rad3-related (ATR) kinase is crucial for DNA
damage and replication stress responses. Here, we describe an unexpected role of ATR in …

The evolutionally conserved DNA damage response (DDR) and cell cycle checkpoints
preserve genome integrity. Central to these genome surveillance pathways is a protein …

Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player
in chromosome segregation. As part of a macromolecular complex known as the …

Chromosomal aberrations during cell division represent one of the first recognized features
of human cancer cells, and modern detection methods have revealed the pervasiveness of …

DNA damage response genes play vital roles in the maintenance of a healthy genome.
Defects in cell cycle checkpoint and DNA repair genes, especially mutation or aberrant …

Originally identified as a mediator of DNA damage response (DDR), checkpoint kinase 1
(Chk1) has a broader role in checkpoint activation in DDR and normal cell cycle regulation …

The DNA damage response (DDR) represents a complex network of multiple signaling
pathways involving cell cycle checkpoints, DNA repair, transcriptional programs, and …