Synthetic progestogens (progestins) have been linked to increased breast cancer risk;
however, the role of endogenous progesterone in breast physiology and carcinogenesis is …

The functional capacity of organisms declines in the process of aging. In the case of breast
tissue, abnormal mammary gland development can lead to dysfunction in milk secretion, a …

Recent studies have documented frequent evolution of clones carrying common cancer
mutations in apparently normal tissues, which are implicated in cancer development …

Abstract Hormone receptor-positive (HR+) breast cancer (BC) is the most common type of
breast cancer among women worldwide, accounting for 70–80% of all invasive cases …

Ondansetron is commonly used in breastfeeding mothers to treat nausea and vomiting.
There is limited information in humans regarding safety of ondansetron exposure to nursing …

The stromal microenvironment regulates mammary gland development and tumorigenesis.
In normal mammary glands, the stromal microenvironment encompasses the ducts and …

Background Among women diagnosed with invasive breast cancer, 30% have a prior
diagnosis of benign breast disease (BBD). Thus, it is important to identify factors among BBD …

Second harmonic generation (SHG) microscopy is acknowledged as an established
imaging technique capable to provide information on the collagen architecture in tissues that …

Lesser degrees of terminal duct-lobular unit (TDLU) involution predict higher breast cancer
risk; however, standardized measures to quantitate levels of TDLU involution have only …

Background Emerging data indicate that variations in quantitative epithelial and stromal
tissue composition and their relative abundance in benign breast biopsies independently …