Skeletal muscle, a highly complex muscle type in the eukaryotic system, is characterized by
different muscle subtypes and functions associated with specific myosin isoforms. As a …

Phosphorylation of cardiac myosin binding protein-C (cMyBP-C) accelerates cardiac
contractility. However, the mechanisms by which cMyBP-C phosphorylation increases …

Heat shock protein 90 (Hsp90) is a molecular chaperone that interacts with up to 10% of the
proteome. The extensive involvement in protein folding and regulation of protein stability …

Rationale: cMyBP-C (cardiac myosin-binding protein-C) is a critical regulator of heart
contraction, but the mechanisms by which cMyBP-C affects actin and myosin are only partly …

1Physics, Florida State Univ, Tallahassee, FL, USA, 2Florida State Univ, Tallahassee, FL,
USA, 3Biology, Florida State Univ, Tallahassee, FL, USA. Striated muscle thick filaments are …

Troponin I (TnI) is a key regulator of cardiac contraction and relaxation with TnI Ser-23/24
phosphorylation serving as a myofilament mechanism to modulate cardiac function. Basal …

The Frank–Starling relationship establishes that elevated end-diastolic volume
progressively increases ventricular pressure and stroke volume in healthy hearts. The …

PKA-mediated phosphorylation of sarcomeric proteins enhances heart muscle performance
in response to β-adrenergic stimulation and is associated with accelerated relaxation and …

Cardiac myosin-binding protein C (cMyBP-C) is a thick filament-associated protein of the
sarcomere and a potential therapeutic target for treating contractile dysfunction in heart …

Heart failure arises, in part, from a constellation of changes in cardiac myocytes including
remodeling, energetics, Ca2+ handling, and myofibrillar function. However, little is known …