TSNAdb v2. 0: the updated version of tumor-specific neoantigen database
In recent years, neoantigens have been recognized as ideal targets for tumor
immunotherapy. With the development of neoantigen-based tumor immunotherapy …
immunotherapy. With the development of neoantigen-based tumor immunotherapy …
Identification of cancer hotspot residues and driver mutations using machine learning
Cancer is one of the most life-threatening diseases and mutations in selected genes are
associated with tumorigenesis. Identification of driver mutations, which are responsible for …
associated with tumorigenesis. Identification of driver mutations, which are responsible for …
Unraveling the Drivers of Tumorigenesis in the Context of Evolution: Theoretical Models and Bioinformatics Tools
X Zhu, W Zhao, Z Zhou, X Gu - Journal of Molecular Evolution, 2023 - Springer
Cancer originates from somatic cells that have accumulated mutations. These mutations
alter the phenotype of the cells, allowing them to escape homeostatic regulation that …
alter the phenotype of the cells, allowing them to escape homeostatic regulation that …
dN/dS-H, a New Test to Distinguish Different Selection Modes in Protein Evolution and Cancer Evolution
X Gu - Journal of Molecular Evolution, 2022 - Springer
One of the most popular measures in the analysis of protein sequence evolution is the ratio
of nonsynonymous distance (d N) to synonymous distance (d S). Under the assumption that …
of nonsynonymous distance (d N) to synonymous distance (d S). Under the assumption that …
The theory of massively repeated evolution and full identifications of Cancer Driving Nucleotides (CDNs)
Tumorigenesis, like most complex genetic traits, is driven by the joint actions of many
mutations. At the nucleotide level, such mutations are Cancer Driving Nucleotides (CDNs) …
mutations. At the nucleotide level, such mutations are Cancer Driving Nucleotides (CDNs) …
Evolution and functional divergence of the ERBB receptor family
Aim: The ERBB gene family plays an important role in cell proliferation and differentiation,
and aberrant activations could result in tumorigenesis, which makes this gene family an …
and aberrant activations could result in tumorigenesis, which makes this gene family an …
[HTML][HTML] Antibody-Like Phosphorylation Sites. Theme for Studies of Cancer, Aging and Evolution
J Kubrycht, K Sigler - Computational Molecular Bioscience, 2022 - scirp.org
Sequence similarities were found between protein and DNA sequences encoding certain
part of conserved variable immunoglobulin domains (ie conserved IgV) and phosphorylation …
part of conserved variable immunoglobulin domains (ie conserved IgV) and phosphorylation …